P096 Objective Measures of Sleep Architecture in Adults and Older Adults with Depression: A Systematic Review and Meta-Analysis

Abstract Depression is intrinsically linked to sleep, however, the exact nature of sleep disturbances has been poorly defined, especially for older adults over 50 years with depression. We examined published articles overnight EEG recordings in and without depression determine if objective measures macro micro architecture differ. also differences these outcomes adults. 2135 papers were identified through four databases. Two reviewers, using PICO structure, removed 2062 at abstract review 58 full text review. Fifteen met inclusion criteria reported macroarchitecture. Three microarchitectural but not meta-analysed. RevMan 5.4 software was used perform a random effects model meta-analysis. NICE case-control guidelines risk bias. studies assessed (406 depressed 432 control). (31 31 controls). Within total population, had less time, lower efficiency(SE), delayed onset latency, higher wake after onset, shorter rapid eye movement latency(ROL) greater REM density than controls. No stage 1(N1), 2(N2), 3(N3) or observed. In adults, group N1, N2, ROL, no difference SE duration. latency consistent across younger groups, whereas worse continuity. Differences phenotype may relate underlying neuropathology.